chromothripsis
Word Rarity
Very rare
Frequency: Zipf frequency 0.00 in modern English
26
Scrabble Score
14
Letters
4
Syllables
9
Unique Chars
Meaning
Example Sentences
- "But for 2—3% of cancers, particularly bone cancer (up to 25%), recent evidence suggests that a single event of chromothripsis involving one or a few chromosomes leads to multiple gene rearrangements (in some cases tens to hundreds) that can disrupt tumor suppressor genes and/or produce oncogenic fusion genes."
- "Another new phenomenon described by Stephens et al.[86] is called “chromothripsis”. Chromothripsis describes a massive genomic rearrangement in one or more chromosomes in a single catastrophic event during the cells' history,"
- "Some of the characteristics of chromothripsis are oscillating copy number changes, clustering of breakpoints, localized rearrangements involving one or a part of a chromosome, and complex rearrangements."
Etymology
From Ancient Greek χρῶμα (khrôma, “colour”) (referring to English chromo(some)) + θρίψις (thrípsis, “shattering into pieces”) (from τρίβω (tríbō, “I rub”).