vexas
Word Rarity
Very rare
Frequency: Zipf frequency 0.00 in modern English
15
Scrabble Score
5
Letters
1
Syllables
5
Unique Chars
Meaning
Example Sentences
- "Using a genotype-driven approach, we identified a disorder that connects seemingly unrelated adult-onset inflammatory syndromes. We named this genetic disorder the VEXAS syndrome, which is caused by myeloid-restricted somatic missense mutations in UBA1."
- "Additionally, patients with VEXAS suffer from a spectrum of hematologic problems, including macrocytic anemia, thrombocytopenia, thromboembolic disease, and progressive bone marrow failure, which can evolve to hematologic malignancy"
- "The researchers note that a diagnosis based on symptoms alone could easily miss cases of VEXAS that would be caught by UBA1 testing."
Etymology
Acronym of vacuoles, E1 enzyme, X chromosome, autoinflammatory, somatic, after the core features of the disorder. First discovered in October 2020, with the report from The New England Journal of Medicine and identified by a multidisciplinary team of scientists (see quotations below).