alexander disease

Questions

What does alexander disease mean?

A rare, progressive, and usually fatal neurological disorder; classified as a leukodystrophy, it is fundamentally a disease of the brain’s astrocytes; caused by genetic mutations that lead to the abnormal accumulation of proteins, known as Rosenthal fibers, which destroy the protective myelin sheath in the central nervous system.

Where does alexander disease come from?

Named after the American physician Dr. W. Stewart Alexander, who was the first to describe the disorder in 1949.

How to pronounce alexander disease

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