resiniferatoxin
Word Rarity
Very rare
Frequency: Zipf frequency 0.00 in modern English
25
Scrabble Score
15
Letters
4
Syllables
10
Unique Chars
Meaning
noun
A naturally occurring ultrapotent capsaicin analogue (having in its pure form a Scoville heat unit measure of 16,000,000,000) that activates the receptor TRPV1 (aka vanilloid receptor 1 or the capsaicin receptor) in a subpopulation of primary afferent sensory neurons involved in nociception.
Uncountable
Example Sentences
- "1992, Arpad Szallasi, Peter M. Blumberg, 27: Resiniferatoxin, P. Michael Conn (editor), Neurotoxins, Harcourt Brace Jovanovich (Academic Press), page 368, An exciting recent advance in the vanilloid field has been our discovery that resiniferatoxin (RTX), a naturally occurring diterpene combining structural features of the phorbol ester tumor promoters and of capsaicin (see structures in Fig. 1), functions as an ultrapotent capsaicin analog (4—6) and that the esterification of other phorbol-related diterpenes with homovanillic acid at the C-20 position yields synthetic vanilloids of the RTX class with unique spectra of action (7)."
- "They both cause an initial stimulation and inflammation, capsaicin much more so than resiniferatoxin."
- "In heterologous expression systems, TRPV1 can be activated not only by vanilloid compounds, but also by resiniferatoxin, extracellular protons, and arachidonic acid metabolites."