Speakur

Word Pronunciation & Dictionary

lipinski's rule of five

Word Rarity Very rare

Frequency: Zipf frequency 0.00 in modern English

Syllables
lip-in-ski's rule of -five
IPA
34
Scrabble Score
19
Letters
4
Syllables
12
Unique Chars

Meaning

name

A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5.

Etymology

The rule was formulated by Christopher A. Lipinski in 1997. Five refers to the multiples of five that occur in all of the criteria.

Synonyms

Pfizer's rule of five RO5 rule of five

Questions

What does lipinski's rule of five mean?
A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5.
Where does lipinski's rule of five come from?
The rule was formulated by Christopher A. Lipinski in 1997. Five refers to the multiples of five that occur in all of the criteria.

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