parthanatos
Word Rarity
Very rare
Frequency: Zipf frequency 0.00 in modern English
16
Scrabble Score
11
Letters
1
Syllables
8
Unique Chars
Meaning
Example Sentences
- "Our results suggest that excessive activation of PARP-1 leads to an intrinsic cell death program, which we designate as parthanatos to distinguish from necrosis and apoptosis."
- "Also, the lack of knowledge of mechanisms of calpain activation in parthanatos makes it difficult to identify calpain as PAR-dependent mediators of AIF release."
- "The biochemical features of parthanatos are distinct from classically defined pathways of cell death, and include rapid PARP-1 activation, early PAR accumulation, mitochondrial depolarization, early nuclear AIF translocation, loss of cellular NAD and ATP, and late caspase activation."