autoimmunity
/ˌɔːtoʊɪˈmjuːnɪti/
Word Rarity
Very rare
Frequency: 2.19 in modern English
19
Scrabble Score
12
Letters
5
Syllables
8
Unique Chars
Meaning
noun
The condition where one's immune system attacks one's own tissues, i.e., an autoimmune disorder.
Countable; Uncountable
Example Sentences
- "This can be demonstrated in NOD mice in which a point mutation in the autoimmune regulator (Aire) gene results in the reduced expression of P0 in the thymus and a concomitant increase of P0 specific T cells in the periphery. 107 Similarly, autoimmunity is shifted towards the peripheral nerve in another NOD model deficient for isoforms of ICAM-1. 108 Altered expression of ICAM-1 on thymic epithelial cells transforms selection of T cells from a diabetogenic into a neuritogenic repertoire. 108 Studies such as these highlight the critical role of regulatory mechanisms in maintaining immune homeostasis and the impact that changes to regulation can have on the development of disease."
- "Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE)."
Etymology
Etymology tree Proto-Indo-European *h₂ew Proto-Indo-European *tó- Proto-Hellenic *autós Proto-Indo-European *h₂ewder. Ancient Greek αὖ (aû) Ancient Greek τόν (tón) Ancient Greek αὐτός (autós) Ancient Greek αὐτο- (auto-)lbor. English auto- English immunity English autoimmunity From auto- + immunity.
Regional Pronunciation
- American English: /ˌɔːtoʊɪˈmjuːnɪti/
- British English: /ˌɔː.təʊ.ɪˈmjuː.nɪ.ti/