original antigenic sin

Questions

What does original antigenic sin mean?

The propensity of the immune system to preferentially use immunological memory based on a previous infection when a second, slightly different version of the foreign pathogen is encountered, leaving the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections.

Where does original antigenic sin come from?

See original sin.

How to pronounce original antigenic sin

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